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      《Chinese Journal of Critical Care Medicine》 2019-04
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      Attention should be paid to non-hepatic hyperammonemia in severe patients

      Yao Zhi-peng;Wang Hong-liang;Intensive Care Unit,the Second Hospital Affliated Harbin Medical University;  
      As the main metabolite of amino acid in vivo,blood ammonia plays an important role in the process of material metabolism and biotransformation.Current studies tend to focus on the theory of high blood ammonia and ammonia poisoning caused by liver diseases,but the reasons for the increase of blood ammonia caused by non-liver diseases and the effects of high blood ammonia on other organ functions have been neglected.At present,it is believed that the increase of blood ammonia caused by other causes in patients without hepatic disease(acute liver failure or chronic liver disease)is referred to as non-hepatic hyperammonemia(NHH).However,at present,NHH has not been paid much attention by the clinicians.In this paper,the pathophysiological mechanism,clinical significance and the relationship between blood ammonia and disease in severe patients with NHH are discussed in the hope of that it will be helpful to clinical diagnosis,assessment and treatment of related diseases.
      【Fund】: 哈尔滨市科技局(2016RAQXJ154)
      【CateGory Index】: R459.7
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      【Citations】
      Chinese Journal Full-text Database 1 Hits
      1 Ming Luo;Jian-Yang Guo;Wu-Kui Cao;Department of Gastroenterology,Ningxia People’s Hospital;Tianjin Liver Disease Institute, Tianjin Second People’s Hospital;;Inflammation:A novel target of current therapies for hepatic encephalopathy in liver cirrhosis[J];World Journal of Gastroenterology;2015-41
      【Co-citations】
      Chinese Journal Full-text Database 3 Hits
      1 Yao Zhi-peng;Wang Hong-liang;Intensive Care Unit,the Second Hospital Affliated Harbin Medical University;;Attention should be paid to non-hepatic hyperammonemia in severe patients[J];中国急救医学;2019-04
      2 Xun Xiaoli;Xun Xiaoqin;Department of Gastroenterology,the Hospital of Shanxi General Team of Armed Police;Department of Neurology,the People's Hospital of Taiyuan;;Correlation analysis between serum ammonia,serum IL-18 levels and hepatic encephalopathy caused by hepatocirrhosis[J];中国基层医药;2019-03
      3 Hou Yuli;Gao Mengdan;Guo Hongyan;Wang Rui;Wang Zhong;Yu Yanhua;Lou Jinli;Zhao Yan;Clinical Laboratory Center,You'an Hospital, Capital Medical University;;Diagnostic value of albumin-bilirubin grade combined with serum ammonia in cirrhosis with hepatic encephalopathy[J];中华医学杂志;2018-02
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      Chinese Journal Full-text Database 3 Hits
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